Ameliorative effect of vitamin e on oxidative stress induced by bisphenol a in female albino rats

Objective: Oxidative stress is induced by bisphenol A [BPA] and affects many organs. Vitamin E is an effective antioxidant which prevents the activity of free radicals. This study was aimed to clarify the effect of vitamin E on the oxidative stress induced by chronic administration of BPA

Materials and methods: 30 female albino rats were divided into 3 groups [10/each]; group1: control rats, group 2: rats treated with bisphenol A [20 mg/ kg.B.wt] for three months, and group 3: rats treated with bisphenol A [20 mg/kg.B.wt] for three months, then treated with BPA and vitamin E [0.57/100 g B.wt] for other 15 days

Results: BPA induced hormonal disrupt in liver and kidney dysfunctions and hyperlipidemia. Vitamin E ameliorated all these parameters

Conclusion: since we exposed to many harmful disruptions and oxidative stress compounds, we must take vitamin E as a protective agent

Study of the relation of interleukin-6, essential fatty acids, and estrogen in bone metabolism in elderly women

The aim of this study was to evaluate and assess the relation of interleukin-6, essential fatty acids, and estrogen to the development of osteoporosis in women of different age groups. This study was carried on 40 women divided in two groups: the first group [GI] included 20 apparently healthy women above 65 years and the second group [GII] included 20 healthy women between 20-30 years of age. Serum osteocalcin, estrogen, interleukin-6 by ELISA, Urinary hydroxyproline by ELISA, essential fatty acid in the blood by Gas Liquid Chromatography, serum calcium, and phosphorus were estimated as well as bone density. The current study revealed a significant decrease of serum estrogen in GI when compared to GII [p<0.05], a significant increase of serum interleukin-6, osteocalcin, urinary hydroxyproline in GI when compared to GII [p<0.05], a significant decrease of bone density in GI when compared to GII [p<0.05]. A significant strong positive correlation between interleukin-6 and bone density in both groups were found. From this study, it is concluded that low estrogen level and high interleukin-6 could be used as a predictor for the occurrence of low bone density and the production of osteoporosis with the subsequent occurrence of fractures in post menopausal women

Portal vein hemodynamics, congestion index in chronic liver diseases using doppler echosonography.

This study included sixty patients with chronic liver disease [CLD] and twenty healthy controls of comparable age and sex. The duplex study of portal vein revealed a significant increase in cross- sectional area in the patients groups compared with the controls. Also, a significant reduction in portal vein velocity in patients than the controls was found and only a significant increase in portal venous flow in group III compared with the controls. Congestion index was increased in all patients groups compared with the controls. On comparing group I versus group II or group III, there was only a significant increase in portal venous flow in group III versus group I, but congestion index was significantly increased in groups II and III, respectively, versus group I